Peripheral artery disease (PAD)—a narrowing of the arteries serving the legs and feet —affects as many as 12 million Americans and 200 million people worldwide. It is a manifestation of clogged arteries, but until now, scientists lacked information about why some people with the disease presented with problems with their legs, some with their heart and some with strokes.
source https://www.lifetechnology.com/blogs/life-technology-news-blog/genetic-characteristics-of-peripheral-artery-disease